Date Published: May 01, 2012
Publisher: International Union of Crystallography
Author(s): Meng Xie, Si-Si Shen, Bao-Feng Chen, Yu Sha.
In the title compound, C20H29NO8S, the two five-membered rings adopt envelope conformations (with an O atom at the flap in each case), while the six-membered pyran ring displays a twist-boat conformation. In the crystal, molecules are linked by N—H⋯O hydrogen bonds into a supramolecular chain running along the a axis.
For general background to the drug topiramate [systematic name: 2,3:4,5-bis-O-(1-methylethylidene)-beta-d-fructopyranose sulfamate] and its potential bioactivity, see: Maryanoff (2009 ▶); Maryanoff et al. (2008 ▶). For related structures, see: Maryanoff et al. (1998 ▶); Winum et al. (2006 ▶).