Research Article: 4-[(1,3-Thia­zol-2-yl)sulfamo­yl]phenyl 2,2,2-trifluoro­acetate

Date Published: April 01, 2012

Publisher: International Union of Crystallography

Author(s): Abdullah M. Asiri, Hassan M. Faidallah, Khalid A. Alamry, Seik Weng Ng, Edward R. T. Tiekink.


In the title compound, C11H7F3N2O4S2, the 1,3-thia­zol-2-amine residue is almost perpendicular to the central benzene ring [dihedral angle = 84.3 (2)°]. There is a small twist between the benzene ring and the ester group [C—O—C—C torsion angle = 9.8 (6)°]. Thus, the mol­ecule has an L-shape. Inversion-related dimers are connected in the crystal packing by pairs of N—H⋯N hydrogen bonds formed between the amine H and thia­zole N atom via eight-membered {⋯HNCN}2 synthons.

Partial Text

For the biological efficacy of F and CF3 in medicinal chemistry, see: Fokin & Kolomiyets (1988 ▶); Bonacorso et al. (2006 ▶). For background to the biological applications of sulfonamides, see: Croitoru et al. (2004 ▶); Dogruer et al. (2010 ▶). For related structures, see: Asiri et al. (2011 ▶, 2012 ▶).