Research Article: 4-(2-Oxa-6-aza­spiro­[3.3]hept-6-yl)­benzo­nitrile

Date Published: May 01, 2010

Publisher: International Union of Crystallography

Author(s): Jian Li, Ting Xu, Peng-Bo Wu, Jing Lu, Yao Tang.

http://doi.org/10.1107/S1600536810012936

Abstract

In the title compound, C12H12N2O, the azetidine ring (r.m.s. deviation = 0.021 Å) and the oxetane ring (r.m.s. deviation = 0.014 Å) are nearly perpendicular to each other [dihedral angle = 89.7 (1)°]. The azetidine ring is twisted out of the plane of the benzene ring by 18.3 (1)°. In the crystal structure, mol­ecules are linked to form chains along the c axis by C—H⋯O hydrogen bonds.

Partial Text

The title compound is a key inter­mediate to synthesize (pyrrolo[3,4-c]pyrazol-3-yl)benzamide derivatives. For the anti-tumor effect of these derivatives, see: Fancelli et al. (2005 ▶).

 

Source:

http://doi.org/10.1107/S1600536810012936

 

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