Research Article: 4-(4-Amino-2-fluoro­phen­oxy)-7-meth­oxy­quinazolin-6-ol methanol monosolvate

Date Published: April 01, 2012

Publisher: International Union of Crystallography

Author(s): Wei Huang, Aimin Tan.


In the title compound, C15H12FN3O3·CH3OH, the dihedral angle between the quinazoline ring system and the benzene ring is 81.18 (9)°. In the crystal, mol­ecules are linked by N—H⋯O and O—H⋯N hydrogen bonds, generating [10-1] chains of alternating main mol­ecules and solvent mol­ecules. Weak C—H⋯O inter­actions are also observed.

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For background to quinazolinones, see: Priya et al. (2011 ▶). For further synthetic details, see: Furuta et al. (2006 ▶).