Research Article: 4-(4-Fluoro­phen­yl)-1-(4-nitro­phen­yl)-3-(pyridin-4-yl)-1H-pyrazol-5-amine

Date Published: March 01, 2012

Publisher: International Union of Crystallography

Author(s): Bassam Abu Thaher, Pierre Koch, Dieter Schollmeyer, Stefan Laufer.

http://doi.org/10.1107/S1600536812004102

Abstract

In the crystal structure of the title compound, C20H14FN5O2, the pyrazole ring forms dihedral angles of 59.3 (2), 25.6 (2) and 46.0 (2)° with the directly attached 4-fluoro­phenyl, pyridine and nitro­phenyl rings, respectively. The crystal packing is characterized by inter­molecular N—H⋯N and N—H⋯O hydrogen bonds.

Partial Text

For p38α MAP kinase inhibitors having a vicinal 4-fluoro­phen­yl/pyridin-4-yl system connected to a five-membered heterocyclic core, see: Abu Thaher et al. (2009 ▶); Peifer et al. (2006 ▶). For inhibitory activity and preparation of the title compound, see: Abu Thaher et al. (2012 ▶).

 

Source:

http://doi.org/10.1107/S1600536812004102