Research Article: 4-(4-Fluoro­phen­yl)-1-(4-nitro­phen­yl)-3-(pyridin-4-yl)-1H-pyrazol-5-amine

Date Published: March 01, 2012

Publisher: International Union of Crystallography

Author(s): Bassam Abu Thaher, Pierre Koch, Dieter Schollmeyer, Stefan Laufer.


In the crystal structure of the title compound, C20H14FN5O2, the pyrazole ring forms dihedral angles of 59.3 (2), 25.6 (2) and 46.0 (2)° with the directly attached 4-fluoro­phenyl, pyridine and nitro­phenyl rings, respectively. The crystal packing is characterized by inter­molecular N—H⋯N and N—H⋯O hydrogen bonds.

Partial Text

For p38α MAP kinase inhibitors having a vicinal 4-fluoro­phen­yl/pyridin-4-yl system connected to a five-membered heterocyclic core, see: Abu Thaher et al. (2009 ▶); Peifer et al. (2006 ▶). For inhibitory activity and preparation of the title compound, see: Abu Thaher et al. (2012 ▶).