Date Published: March 01, 2012
Publisher: International Union of Crystallography
Author(s): Bassam Abu Thaher, Pierre Koch, Dieter Schollmeyer, Stefan Laufer.
In the title compound, C20H15FN4, the pyrazole ring forms dihedral angles of 43.51 (6), 39.95 (6) and 32.23 (6)° with the directly attached 4-fluorophenyl, pyridine and phenyl rings, respectively. The crystal packing is stabilized by intermolecular N—H⋯N and N—H⋯F hydrogen bonds.
For p38α MAP kinase inhibitors having a vicinal 4-fluorophenyl/pyridin-4-yl system connected to a five-membered heterocyclic core, see: Abu Thaher et al. (2009 ▶); Peifer et al. (2006 ▶). For inhibitory activity and preparation of the title compound, see: Abu Thaher et al. (2012 ▶).