Research Article: 4-[(4-Methyl­benzene­sulfonamido)­meth­yl]cyclo­hexa­necarb­oxy­lic acid

Date Published: July 01, 2011

Publisher: International Union of Crystallography

Author(s): Muhammad Ashfaq, Samina Iram, Mehmet Akkurt, Islam Ullah Khan, Ghulam Mustafa, Shahzad Sharif.


The title compound, C15H21NO4S, crystallized with two independent mol­ecules in the asymmetric unit in which the dihedral angles between the mean planes of the benzene and cyclo­hexane rings are 78.3 (2) and 67.6 (2)°. The substituents of the cyclo­hexyl rings are in equatorial orientations. In the crystal, both mol­ecules form R22(6) carb­oxy­lic acid inversion dimers via pairs of O—H⋯O hydrogen bonds. Further N—H⋯O and C—H⋯O inter­actions generate a three-dimensional network.

Partial Text

For background to tranexamic acid, see: Boylan et al. (1996 ▶); Nilsson (1980 ▶); Khan et al. (2002 ▶); Shah et al. (2010 ▶); Shahzadi et al. (2007 ▶); Svahn et al. (1986 ▶); Vávrová et al. (2005 ▶).




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