Date Published: July 01, 2011
Publisher: International Union of Crystallography
Author(s): Muhammad Ashfaq, Samina Iram, Mehmet Akkurt, Islam Ullah Khan, Ghulam Mustafa, Shahzad Sharif.
The title compound, C15H21NO4S, crystallized with two independent molecules in the asymmetric unit in which the dihedral angles between the mean planes of the benzene and cyclohexane rings are 78.3 (2) and 67.6 (2)°. The substituents of the cyclohexyl rings are in equatorial orientations. In the crystal, both molecules form R22(6) carboxylic acid inversion dimers via pairs of O—H⋯O hydrogen bonds. Further N—H⋯O and C—H⋯O interactions generate a three-dimensional network.
For background to tranexamic acid, see: Boylan et al. (1996 ▶); Nilsson (1980 ▶); Khan et al. (2002 ▶); Shah et al. (2010 ▶); Shahzadi et al. (2007 ▶); Svahn et al. (1986 ▶); Vávrová et al. (2005 ▶).