Date Published: August 01, 2012
Publisher: International Union of Crystallography
Author(s): Mostafa M. Ghorab, Mansour S. Al-Said, Abdullah A. Al-Mishari, Ching Kheng Quah, Hoong-Kun Fun.
In the title compound, C16H12F3N3O2S·0.47C2H5OH·0.53CH3OH, the quinoline ring system is approximately planar, with a maximum deviation of 0.035 (3) Å, and makes a dihedral angle of 52.67 (9)° with the benzene ring. The F atoms of the –CF3 group are disordered over two orientations, with refined site occupancies of 0.56 (2) and 0.44 (2). A single solvate site is occupied at random by ethanol or methanol, with refined site occupancies of 0.470 (6) and 0.530 (6), respectively. In the crystal, molecules are linked via N—H⋯O, N—H⋯N, O—H⋯O and C—H⋯O hydrogen bonds, thereby forming sheets lying parallel to (010).
For background to the biological and pharmacological activity of quinolines, see: Ghorab et al. (2011 ▶, 2012 ▶).