Date Published: May 01, 2012
Publisher: International Union of Crystallography
Author(s): Hoong-Kun Fun, Tze Shyang Chia, Poovan Shanmugavelan, Alagusundaram Ponnuswamy.
In the title compound, C21H23NOS, the thiazolidine ring adopts a twist conformation about one of its C—S bonds, while the cyclohexane ring has a chair conformation. The S and N atoms attached to the spiro C atom are in axial and equatorial orientations, respectively. The thiazolidine ring forms dihedral angles of 86.24 (14) and 31.82 (15)° with the directly attached and remote terminal benzene rings, respectively. The dihedral angle between the two terminal benzene rings is 86.74 (14)°. In the crystal, the only significant directional interaction is a weak C—H⋯π bond, which generates  chains.
For the pharmacological activity of spirothiazolidin-4-ones, see: Singh et al. (2006 ▶); Kasimogullari & Cesur (2004 ▶); Dandia et al. (2004 ▶); Sahu et al. (2006 ▶). For a related structure, see: Akkurt et al. (2008 ▶). For ring puckering parameters, see: Cremer & Pople (1975 ▶). For the stability of the temperature controller used for data collection, see: Cosier & Glazer (1986 ▶). For standard bond lengths, see: Allen et al. (1987 ▶).