Date Published: February 01, 2012
Publisher: International Union of Crystallography
Author(s): Wei-Gao Pan, Zhi-Dong Zhao, Peng Luo, Cui-Wu Lin, Jian-Hua Miao.
The title compound, C19H19N3O7S·CH3OH, was synthesized from syringic acid and sulfamethoxazole. The benzene rings make a dihedral angle of 41.8 (1)° and the isoxazole ring is twisted by 74.3 (1)° from the central benzene ring. The crystal packing features O—H⋯O and O—H⋯N hydrogen bonds in which the hydroxy groups from the main molecule and methanol solvent molecules serve as donor groups.
For the biological activity of syringic acid and sulfamethoxazole, see: Wu et al. (2009 ▶); Itoh et al. (2009 ▶, 2010 ▶); Ramachandran & Raja (2010 ▶); Ma et al. (2007 ▶); Hida et al. (2005 ▶); Liu et al. (2003 ▶). For related structures, see: Camerman et al. (1979 ▶); Yan et al. (2009 ▶); Yasmeen et al. (2010 ▶).