Research Article: 4-Methyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one monohydrate

Date Published: June 01, 2010

Publisher: International Union of Crystallography

Author(s): Asmaa Saber, Hafid Zouihri, El Mokhtar Essassi, Seik Weng Ng.

http://doi.org/10.1107/S1600536810017885

Abstract

The seven-membered fused-ring in the title compound, C10H10N2O·H2O, adopts a boat conformation (with the two phenyl­ene C atoms representing the stern and the methyl­ene C atom the prow). In the crystal, two benzodiazepinone mol­ecules are linked about a center of inversion by diazepine–carbonyl N—H⋯O hydrogen bonds. The dimers are further linked by water–diazepine O—H⋯N hydrogen bonds, forming a linear chain.

Partial Text

For background to the synthesis and biological activity of benzodiazepines, see: Ahabchane et al. (1999 ▶). For the microwave-assisted synthesis, see: Koizumi (2006 ▶). For a related structure, see: Saber et al. (2010 ▶).

Source:

http://doi.org/10.1107/S1600536810017885