Research Article: 4,7-Dichloro­quinoline

Date Published: May 01, 2012

Publisher: International Union of Crystallography

Author(s): Amol A. Kulkarni, Christopher King, Ray J. Butcher, Joseph M. D. Fortunak.


The two mol­ecules in the asymmetric unit of the title compound, C9H5Cl2N, are both essentially planar (r.m.s. deviations for all non-H atoms = 0.014 and 0.026 Å). There are no close C—H⋯Cl contacts.

Partial Text

4,7-dichloro­quinoline is a commonly used starting material for the synthesis of a variety of anti-malarial drugs, such as amodiquine {systematic name: 4-[(7-chloro­quinolin-4-yl)amino]-2-[(diethyl­amino)­meth­yl]phenol}, see: Dongre et al. (2007 ▶); O’Neill et al. (2003 ▶); Lawrence et al. (2008 ▶); Saha et al. (2009 ▶).