Date Published: April 01, 2011
Publisher: International Union of Crystallography
Author(s): J. Kalyana Sundar, B. Devi Bala, S. Natarajan, J. Suresh, P. L. Nilantha Lakshman.
The piperidine ring of the title compound, C30H26Cl2FN3O2, adopts a twisted chair conformation. The pyrrolidine ring has a twisted envelope structure with the N atom at the flap [displaced by 0.592 (3) Å]. The fluorooxindole, chlorophenyl and chlorobenzylidene groups are planar with r.m.s. deviations of 0.0348, 0.0048 and 0.0048 Å, respectively. The structure is stabilized by intermolecular N—H⋯O hydrogen bonds.
For biological applications of 1,4-dihydropyridine derivatives, see: Jerom & Spencer (1988 ▶); Perumal et al. (2001 ▶); Hagenbach & Gysin (1952 ▶); Mobio et al. (1989 ▶); Katritzky & Fan (1990 ▶); Ganellin & Spickett (1965 ▶); El-Subbagh et al. (2000 ▶). For their use as synthetic intermediates in the preparation of various pharmaceuticals, see: Wang & Wuorola (1992 ▶). For their ocurrence in natural products such as alkaloids, see: Angle & Breitenbucher (1995 ▶).