Research Article: 5′′-(4-Chloro­benzyl­idene)-4′-(4-chloro­phen­yl)-5-fluoro-1′,1′′-dimethyl­indoline-3-spiro-2′-pyrrolidine-3′-spiro-3′′-piperidine-2,4′′-dione

Date Published: April 01, 2011

Publisher: International Union of Crystallography

Author(s): J. Kalyana Sundar, B. Devi Bala, S. Natarajan, J. Suresh, P. L. Nilantha Lakshman.


The piperidine ring of the title compound, C30H26Cl2FN3O2, adopts a twisted chair conformation. The pyrrolidine ring has a twisted envelope structure with the N atom at the flap [displaced by 0.592 (3) Å]. The fluoro­oxindole, chloro­phenyl and chloro­benzyl­idene groups are planar with r.m.s. deviations of 0.0348, 0.0048 and 0.0048 Å, respectively. The structure is stabilized by inter­molecular N—H⋯O hydrogen bonds.

Partial Text

For biological applications of 1,4-dihydro­pyridine derivatives, see: Jerom & Spencer (1988 ▶); Perumal et al. (2001 ▶); Hagenbach & Gysin (1952 ▶); Mobio et al. (1989 ▶); Katritzky & Fan (1990 ▶); Ganellin & Spickett (1965 ▶); El-Subbagh et al. (2000 ▶). For their use as synthetic inter­mediates in the preparation of various pharmaceuticals, see: Wang & Wuorola (1992 ▶). For their ocurrence in natural products such as alkaloids, see: Angle & Breitenbucher (1995 ▶).




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