Date Published: June 01, 2010
Publisher: International Union of Crystallography
Author(s): Chang-jun Luan, Cheng Guo, Wei Wang, Jian-qiang Wang, Ren-jun Du.
In the title compound, C11H16N4O2, the dihedral angle between the benzene ring and the plane of the four carbon atoms in the piperazine ring is 12.17 (3)°; the latter ring adopts a chair conformation. An intramolecular N—H⋯O hydrogen bond generates an S(6) ring. In the crystal, the molecules are linked by N—H⋯N hydrogen bonds, forming chains.
For bond-length data, see: Allen et al. (1987 ▶). For the synthetic procedure and use of the title compound as an intermediate in the synthesis of tyrosine kinase inhibitors, see: Renhowe et al. (2009 ▶).