Research Article: 5-Bromo-N-(3,4-dimeth­oxy­benz­yl)pyridin-2-amine

Date Published: May 01, 2012

Publisher: International Union of Crystallography

Author(s): Jie Li, Lin-Yan Lu, Wang-Xing Shen, Jian-You Shi.

http://doi.org/10.1107/S1600536812015796

Abstract

The title compound, C14H15BrN2O2, an inter­mediate in drug discovery, was synthesized by the reaction of 5-bromo­pyridin-2-amine and 3,4-dimeth­oxy­benzaldehyde. In the crystal, molecules are linked via pairs ofN—H⋯N hydrogen bonds, leading to the formation of inversion dimers. A short contact occurs between the aryl H atom (ortho position from N) and the centroid of the benzene ring.

Partial Text

For the anti-tumor activity of related compounds, see: Kovala-Demertzi et al. (2007 ▶). For the anti-ulcer activity of related compounds, see: Cho et al. (2001 ▶). For the anti-viral activity of related compounds, see: Mavel et al. (2002 ▶). For the anti-microbial activity of related compounds, see: Yeong et al. (2004 ▶).

 

Source:

http://doi.org/10.1107/S1600536812015796