Research Article: 5-Butyl­amino-2-[2-(dimethyl­amino)eth­yl]-1H-benz[de]isoquinoline-1,3(2H)-dione

Date Published: June 01, 2010

Publisher: International Union of Crystallography

Author(s): Li-Juan Xie.


The title compound, C20H25N3O2, is a new amonafide analogue, which exhibits anti­tumor activity. The asymmetric unit contains two mol­ecules with similar conformations for the substituted aliphatic chains. The two independent mol­ecules form dmers through N—H⋯N hydrogen bonds. The crystal structure is stabilized via π–π stacking inter­actions, the shortest centroid–centroid separation between six-membered rings being 3.673 (2) Å.

Partial Text

For general background to amonafide and its anti­tumour activity, see: Braña et al. (1981 ▶, 2001 ▶); Braña & Ramos (2001 ▶); Ratain et al. (1991 ▶, 1993 ▶). For the synthesis of amonafide analogues, see: Xie et al. (2009 ▶).




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