Date Published: June 01, 2010
Publisher: International Union of Crystallography
Author(s): Li-Juan Xie.
The title compound, C20H25N3O2, is a new amonafide analogue, which exhibits antitumor activity. The asymmetric unit contains two molecules with similar conformations for the substituted aliphatic chains. The two independent molecules form dmers through N—H⋯N hydrogen bonds. The crystal structure is stabilized via π–π stacking interactions, the shortest centroid–centroid separation between six-membered rings being 3.673 (2) Å.
For general background to amonafide and its antitumour activity, see: Braña et al. (1981 ▶, 2001 ▶); Braña & Ramos (2001 ▶); Ratain et al. (1991 ▶, 1993 ▶). For the synthesis of amonafide analogues, see: Xie et al. (2009 ▶).