Research Article: 5-Cyclo­hexyl-3-(4-fluoro­phenyl­sulfon­yl)-2-methyl-1-benzofuran

Date Published: April 01, 2011

Publisher: International Union of Crystallography

Author(s): Hong Dae Choi, Pil Ja Seo, Byeng Wha Son, Uk Lee.


In the title compound, C21H21FO3S, the cyclo­hexyl ring adopts a chair conformation. The 4-fluoro­phenyl ring makes a dihedral angle of 77.71 (4)° with the mean plane of the benzofuran fragment. In the crystal, mol­ecules are linked through inter­molecular C—H⋯O hydrogen bonds and aromatic π–π inter­actions between the furan rings of neighbouring mol­ecules [centroid–centroid distance = 3.578 (2) Å].

Partial Text

For the biological activity of benzofuran compounds, see: Aslam et al. (2006 ▶); Galal et al. (2009 ▶); Khan et al. (2005 ▶). For natural products with benzofuran rings, see: Akgul & Anil (2003 ▶); Soekamto et al. (2003 ▶). For our previous structural studies of related 3-(4-fluoro­phenyl­sulfon­yl)-2-methyl-1-benzo­furan derivatives, see: Choi et al. (2010a ▶,b ▶).




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