Date Published: July 01, 2011
Publisher: International Union of Crystallography
Author(s): Weiyao Wu, Huihui Lin, Chong-Qing Wan, Sheng-Li Cao.
In the title compound, C16H12FNO3, the dihedral angle between the benzene ring and the plane of the indole ring system is 71.60 (6)°. In the crystal, molecules stack along the b axis through π–π interactions between the adjacent indole-2,3-dione units with a centroid–centroid distance of 3.649 (3) Å. Intermolecular C—H⋯O=C and C—H⋯π interactions further stabilize the structure, forming a three-dimensional framework.
For background to the use of 5-fluoroindoline-2,3-dione and its analogues as anti-tumour agents, see: Uddin et al. (2007 ▶); Penthala et al. (2010 ▶). For a related structure, see: Wu et al. (2011 ▶).