Research Article: 5-Fluoro-1-(4-meth­oxy­benz­yl)indoline-2,3-dione

Date Published: July 01, 2011

Publisher: International Union of Crystallography

Author(s): Weiyao Wu, Huihui Lin, Chong-Qing Wan, Sheng-Li Cao.


In the title compound, C16H12FNO3, the dihedral angle between the benzene ring and the plane of the indole ring system is 71.60 (6)°. In the crystal, mol­ecules stack along the b axis through π–π inter­actions between the adjacent indole-2,3-dione units with a centroid–centroid distance of 3.649 (3) Å. Inter­molecular C—H⋯O=C and C—H⋯π inter­actions further stabilize the structure, forming a three-dimensional framework.

Partial Text

For background to the use of 5-fluoro­indoline-2,3-dione and its analogues as anti-tumour agents, see: Uddin et al. (2007 ▶); Penthala et al. (2010 ▶). For a related structure, see: Wu et al. (2011 ▶).




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