Research Article: 5-Methyl-3,3-bis­(morpholin-4-yl)-1-[2-(morpholin-4-yl)eth­yl]-2,3-dihydro-1H-indol-2-one

Date Published: March 01, 2012

Publisher: International Union of Crystallography

Author(s): Hui-Hui Lin, Wei-Yao Wu, Jing-Jing Zhang, Sheng-Li Cao.


In the title compound, C23H34N4O4, the morpholine rings adopt chair conformations. The N atom of the indol-2-one group is linked to the N atom of one morpholine ring through a flexible ethyl group with an almost cif conformation. In the crystal, molecules are linked by C—H⋯O interactions into infinite chains along the c direction. The almost parallel infinite chains are further inter­connected via other sets of C—H⋯O inter­actions, forming a three-dimensional framework.

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For background to and activities of indoline-2,3-dione and its derivatives, see Chiyanzu et al. (2005 ▶); Karali (2002 ▶); Sirisoma et al. (2009 ▶); Solomon et al. (2009 ▶); Sriram et al. (2004 ▶). For structural analogues of indoline-2,3-dione (isatin), see: Wang et al. (2012 ▶).