Research Article: 5-Methyl-N-[2-(trifluoro­meth­yl)phen­yl]isoxazole-4-carboxamide

Date Published: May 01, 2012

Publisher: International Union of Crystallography

Author(s): De-Cai Wang, Jiang-Kai Qiu, Hai-Xi Zhu, Ping Wei, Ping-Kai Ou-Yang.


In the title compound, C12H9F3N2O2, the benzene ring is nearly perpendicular to the isoxazole ring, making a dihedral angle of 82.97 (2)°. In the crystal, mol­ecules are linked by N—H⋯O hydrogen bonds into a supra­molecular chain running along the c axis.

Partial Text

For applications of leflunomide [systematic name: 5-methyl-N-[4-(trifluoro­meth­yl) phen­yl]-isoxazole-4-carboxamide] in the treatment of rheumatoid arthritis, see: Shaw et al. (2011 ▶); Schattenkirchner (2000 ▶). For leflunomide analogs, see: Huang et al. (2003 ▶); Wang et al. (2011 ▶).