Date Published: May 01, 2012
Publisher: International Union of Crystallography
Author(s): De-Cai Wang, Jiang-Kai Qiu, Hai-Xi Zhu, Ping Wei, Ping-Kai Ou-Yang.
In the title compound, C12H9F3N2O2, the benzene ring is nearly perpendicular to the isoxazole ring, making a dihedral angle of 82.97 (2)°. In the crystal, molecules are linked by N—H⋯O hydrogen bonds into a supramolecular chain running along the c axis.
For applications of leflunomide [systematic name: 5-methyl-N-[4-(trifluoromethyl) phenyl]-isoxazole-4-carboxamide] in the treatment of rheumatoid arthritis, see: Shaw et al. (2011 ▶); Schattenkirchner (2000 ▶). For leflunomide analogs, see: Huang et al. (2003 ▶); Wang et al. (2011 ▶).