Research Article: 6′-Methyl-1′,2′,3′,4′-tetra­hydro­spiro­cyclo­hexane-2′-quinazolin-4′-one

Date Published: May 01, 2009

Publisher: International Union of Crystallography

Author(s): Zhang Ling, Daxin Shi, Fan Yanqiu, Xia Wei, Jiarong Li.


The title compound, C14H18N2O, was synthesized by the reaction of cyclo­hexa­none and 2-amino-5-methyl­benzonitrile. In the mol­ecule, the cyclo­hexane ring displays a chair conformation, whereas the 1,3-diaza­cyclo­hexane moiety of the bicyclic system has a sofa conformation with the spiro C atom displaced by 0.603 (2) Å from the rest of the atoms of the 1,3-diaza­cyclo­hexane ring [planar within 0.052 (2) Å]. Mol­ecules are linked into centrosymmetric dimers via N—H⋯O hydrogen bonds.

Partial Text

For medicinal and biological properties of dihydro­quinazolin-4(3H)-one derivatives, see: Jackson et al. (2007 ▶); Shi et al. (2003 ▶, 2004 ▶).




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