Date Published: May 01, 2009
Publisher: International Union of Crystallography
Author(s): Zhang Ling, Daxin Shi, Fan Yanqiu, Xia Wei, Jiarong Li.
The title compound, C14H18N2O, was synthesized by the reaction of cyclohexanone and 2-amino-5-methylbenzonitrile. In the molecule, the cyclohexane ring displays a chair conformation, whereas the 1,3-diazacyclohexane moiety of the bicyclic system has a sofa conformation with the spiro C atom displaced by 0.603 (2) Å from the rest of the atoms of the 1,3-diazacyclohexane ring [planar within 0.052 (2) Å]. Molecules are linked into centrosymmetric dimers via N—H⋯O hydrogen bonds.
For medicinal and biological properties of dihydroquinazolin-4(3H)-one derivatives, see: Jackson et al. (2007 ▶); Shi et al. (2003 ▶, 2004 ▶).