Date Published: March 01, 2012
Publisher: International Union of Crystallography
Author(s): Omar A. Al-Deeb, Ali A. El-Emam, Abdulghafoor A. Al-Turkistani, Seik Weng Ng, Edward R. T. Tiekink.
The title thiouracil derivative, C9H11N3OS, exists in the thione form. The six atoms comprising the ring are almost coplanar [r.m.s. deviation = 0.015 Å] and the 2-methylpropyl group lies approximately perpendicular to this plane [the N—C—C—C torsion angle is 72.88 (14)°]. Linear supramolecular chains along  sustained by N—H⋯O and N—H⋯S hydrogen bonding feature in the crystal packing.
For the biological activity of uracil and pyrimidine derivatives see: Ding et al. (2006 ▶); Hawser et al., (2006 ▶); Brunelle et al. (2007 ▶); Al-Safarjalani et al. (2005 ▶); Al-Omar et al. (2010 ▶); Al-Abdullah et al. (2011 ▶); Al-Turkistani et al. (2011 ▶). For related uracil structures, see: Tiekink (1989 ▶); Nasir et al. (2010 ▶); El-Emam et al. (2011 ▶).