Research Article: 6-Methyl-3-phenyl-2-sulfanyl­idene-1,2,3,4-tetra­hydro­quinazolin-4-one

Date Published: March 01, 2012

Publisher: International Union of Crystallography

Author(s): Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Seik Weng Ng, Edward R. T. Tiekink.


The title compound, C15H12N2OS, exists as the thione tautomer in the solid state. The phenyl group is almost perpendicular [dihedral angle = 87.96 (5)°] to the fused ring system (r.m.s. deviation = 0.036 Å for 13 ring and exocyclic non-H atoms). In the crystal, centrosymmetric dimers, sustained by pairs of N—H⋯S hydrogen bonds, are connected into layers parallel to (-101) by C—H⋯O and C—H⋯S inter­actions.

Partial Text

For recent studies on synthesis, drug discovery and crystal structures of quinazoline-4(3H)-one derivatives, see: El-Azab & El-Tahir (2012 ▶); El-Azab et al. (2011 ▶, 2010 ▶). For the anti­microbial activity of the title compound, see: Al-Omar et al. (2004 ▶). For the structures of related compounds, see: Bowman et al. (2007 ▶); Hashim et al. (2010 ▶).