Research Article: 7-{4-[(1,3-Benzodioxol-5-yl)meth­yl]piperazin-1-yl}-1-cyclo­propyl-6-fluoro-4-oxo-1,4-dihydro­quinoline-3-carb­oxy­lic acid

Date Published: July 01, 2012

Publisher: International Union of Crystallography

Author(s): Shuo Wang, Guangzhi Shan, Huiyuan Guo, Mingliang Liu.

http://doi.org/10.1107/S1600536812028711

Abstract

In the title structure, C25H24FN3O5, a strong intra­molecular O—H⋯O hydrogen bond is present between the carb­oxy group at the 3-position and the carbonyl group at the 4-position. In the crystal, mol­ecules are held together by weak C—H⋯O, C—H⋯F and π–π [centroid–centroid distance 3.6080 (8) Å] inter­actions. The 1,4-dihydro­quinoline ring and cyclo­propyl group are not in the same plane, making an inter­planar angle of 57.52 (8)°.

Partial Text

For the synthesis and properties of quinolone derivatives, see Basuri et al. (2011 ▶); Feng et al. (2011 ▶); Guo et al. (2011 ▶); Liu et al. (2010 ▶); Sharma et al. (2010 ▶); Xu et al. (2007 ▶). For the cryogenic cooler used in the data collection, see Cosier & Glazer (1986 ▶). For hydrogen bonding, see Desiraju & Steiner (1999 ▶).

Source:

http://doi.org/10.1107/S1600536812028711