Date Published: April 01, 2012
Publisher: International Union of Crystallography
Author(s): Marcelle de Lima Ferreira, Marcus V. N. de Souza, Solange M. S. V. Wardell, Edward R. T. Tiekink, James L. Wardell.
In the title compound, C19H18ClN3O3, the r.m.s. deviation through the 23 non-H and non-methoxy atoms is 0.088 Å, indicating a planar molecule with the exception of the methoxy groups. One methoxy group, surrounded on either side by the other methoxy groups, is almost normal to the benzene ring to which it is connected [C—O—Car—Car torsion angle = 81.64 (15)°]. In the crystal, N—H⋯O, C—H⋯O and π–π interactions [between quinoline residues; centroid–centroid distance = 3.4375 (8) Å] link molecules into a three-dimensional architecture.
For the biological activity, including anti-tubercular and anti-tumour activity, of compounds containing the quinolinyl nucleus, see: de Souza et al. (2009 ▶); Candea et al. (2009 ▶); Montenegro et al. (2012 ▶). For related structures, see: Howie et al. (2010 ▶); de Souza et al. (2010 ▶, 2012 ▶).