Research Article: 7-Chloro-4-[(E)-2-(3,4,5-trimeth­oxy­benzyl­idene)hydrazin-1-yl]quinoline

Date Published: April 01, 2012

Publisher: International Union of Crystallography

Author(s): Marcelle de Lima Ferreira, Marcus V. N. de Souza, Solange M. S. V. Wardell, Edward R. T. Tiekink, James L. Wardell.

http://doi.org/10.1107/S1600536812012755

Abstract

In the title compound, C19H18ClN3O3, the r.m.s. deviation through the 23 non-H and non-meth­oxy atoms is 0.088 Å, indicating a planar mol­ecule with the exception of the meth­oxy groups. One meth­oxy group, surrounded on either side by the other meth­oxy groups, is almost normal to the benzene ring to which it is connected [C—O—Car—Car torsion angle = 81.64 (15)°]. In the crystal, N—H⋯O, C—H⋯O and π–π inter­actions [between quinoline residues; centroid–centroid distance = 3.4375 (8) Å] link mol­ecules into a three-dimensional architecture.

Partial Text

For the biological activity, including anti-tubercular and anti-tumour activity, of compounds containing the quinolinyl nucleus, see: de Souza et al. (2009 ▶); Candea et al. (2009 ▶); Montenegro et al. (2012 ▶). For related structures, see: Howie et al. (2010 ▶); de Souza et al. (2010 ▶, 2012 ▶).

 

Source:

http://doi.org/10.1107/S1600536812012755