Research Article: 7-Chloro-4-(piperazin-1-yl)quinoline

Date Published: May 01, 2012

Publisher: International Union of Crystallography

Author(s): Amol A. Kulkarni, Christopher L. King, Joseph M. D. Fortunak, Ray J. Butcher.


There are two mol­ecules in the asymmetric unit (Z′ = 2) of the title compound, C13H14ClN3, Each mol­ecule is linked by N—H⋯N hydrogen bonds to another of the same type in a chain in [110]. The crystal studied was a non-merohedral twin with components 0.622 (2) and 0.378 (2).

Partial Text

The title compound is an important inter­mediate in the synthesis of the anti-malarial compound piperaquine {systematic name: 7-chloro-4-[4-[3-[4-(7-chloro­quinolin-4-yl)piperazin-1-yl]prop­yl]piperazin-1-yl]quinoline phospho­ric acid}, see: Chen et al. (1982 ▶); Hien et al. (2004 ▶); Dongre et al. (2007 ▶).