Research Article: (9H-Fluoren-9-yl)methyl N-{(2R,3R,4S)-4-hy­droxy-2-[(2S,5R)-2-isopropyl-5-methyl­cyclo­hex­yloxy]-5-oxooxolan-3-yl}carbamate propan-2-ol 0.334-solvate

Date Published: February 01, 2012

Publisher: International Union of Crystallography

Author(s): Graeme J. Gainsford, Andreas Luxenburger.


The title compound, C29H35NO6.0.334C3H8O, a novel chiral N-(fluoren-9-yl­methyl­oxyxcarbon­yl) precursor, crystallizes with two independent carbamate (M) mol­ecules and propan-2-ol solvent mol­ecules in the unit cell. Its crystal structure has been determined from barely adequate data obtained from a multi-fragment needle crystal. In the crystal, N—H⋯O hydrogen bonds link M mol­ecules related by translation along the a axis into two independent chains. The ordered solvent mol­ecule, having a partial occupancy of 0.334, is attached to one independent M mol­ecule through O—H⋯O hydrogen bonds. The crystal packing exhibits weak inter­molecular C—H⋯O inter­actions and voids of 270 Å3 filled with randomly disordered solvent mol­ecules which were handled using the SQUEEZE methodology.

Partial Text

For details of the synthesis, see Harris et al. (2011 ▶). For a related structure, see: Valle et al. (1988 ▶). For hydrogen-bond motifs, see: Bernstein et al. (1995 ▶).