Date Published: October 16, 2008
Publisher: Informa Healthcare
Author(s): B. H. Munkeby, C. De Lange, K. E. Emblem, A. Bjørnerud, G. A. B. Kro, J. Andresen, E. H. Winther-Larssen, E. M. Løberg, J. K. Hald.
Munkeby BH, de Lange C, Emblem KE, Bjørnerud A, Kro GAB, Andresen J, Winther-Larssen EH, Løberg EM, Hald JK. A piglet model for detection of hypoxic-ischemic brain injury with magnetic resonance imaging. Acta Radiol 2008;49:1049–1057.
The experimental protocol was approved by the hospital’s ethics committee for animal studies under the surveillance of the National Animal Research Authority, and performed by certified category C researchers of the Federation of European Laboratory Animal Science Associations.
The availability of a well-controlled piglet model for investigating neonatal injury due to HI is of great importance (17), and in this study we demonstrate correlation between MR findings and histopatho-logical changes in one such model, with results similar to those of a recent retrospective study of human newborns with HI injury (18). In this study, proton spectra were localized to the basal ganglia because previous studies using MRI have identified this area as vulnerable to hypoxia-ischemia injury in neonates (19). Spectra from this region are also less susceptible to interference arising from extracranial fat tissue (20).