Date Published: December 22, 2003
Publisher: Public Library of Science
Author(s): Xiang Yu
Abstract: Tremendous progress has been made towards understanding the molecular mechanisms of Wnt signaling, starting with a group of fruit fly larvae lacking stripes on their cuticles.
Partial Text: The Wnt/Wingless (Wg) pathway is an evolutionarily conserved signaling pathway that plays important roles in normal development and cancer, from worms and flies to mice and humans. Two papers, identifying the first components of this pathway, initiated the active research field of Wnt/Wg signal transduction and profoundly influenced my scientific career.