Research Article: Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats

Date Published: March 18, 2018

Publisher: Tabriz University of Medical Sciences

Author(s): Basiru Olaitan Ajiboye, Oluwafemi Adeleke Ojo, Oluwatosin Adeyonu, Oluwatosin Imiere, Babatunji Emmanuel Oyinloye, Oluwafemi Ogunmodede.


Purpose: Diabetes mellitus is one of the major endocrine disorders, characterized by impaired insulin action and deficiency. Traditionally, Artocarpus heterophyllus stem bark has been reputably used in the management of diabetes mellitus and its complications. The present study evaluates the ameliorative activity of ethanol extract of Artocarpus heterophyllus stem bark in alloxan-induced diabetic rats.

Partial Text

Diabetes mellitus is a chronic metabolic disorder characterized by derangements in carbohydrate, protein and lipid metabolisms, due to defective or deficiency in insulin secretion and action.1 Insulin is a hormone secreted by the beta cells of the Islets of Langerhans of the pancreas, it helps in glucose uptake by the cells, thereby prevents increase in fasting blood glucose levels.2

Ajiboye et al30 reported that plants were endowed with series of secondary metabolites like terpenoids, phenolic, lignins, stilbenes, tannins, flavonoids, quinones, coumarins, alkaloids, amines, betalains amongst others. They were free radical scavenging, making them serve as antioxidant compounds and possess antidiabetic activity amongst others. In this study, the ethanol extract of Artocarpus heterophyllus stem bark demonstrated the presence of saponins (Table 1) which possess cholesterol and fasting blood glucose levels lowering effect making it useful for diabetes mellitus patients.31

The results of the present study show that various doses of ethanol extract of Artocarpus heterophyllus stem bark demonstrates the presence of different phytochemical compounds which serve as antioxidant, therefore improved weight gain, ameliorate anaemia, hyperlipidaemia to normolipidaemia, and demonstrated hepato and nephro-protective in diabetic rats.

The authors are very grateful to all the Technologists in Biochemistry Laboratory of Afe Babalola University, Ado-Ekiti.

The Ethical Committee of the Afe Babalola University approved this study with approval number ABUAD/SCI/004.The study was performed in accordance with the rules of the established Animal Ethical Committee of Afe Babalola University, Ado-Ekiti.

The authors declare no conflict of interest




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