Research Article: An elegans Solution for Crossover Formation

Date Published: July 18, 2013

Publisher: Public Library of Science

Author(s): Stephanie P. Bellendir, Jeff Sekelsky, Michael Lichten

Abstract: None

Partial Text: The MUS-81, SLX-1, and XPF-1 structure-selective endonucleases have been implicated in meiotic crossover (CO) formation in a variety of organisms, but their contributions to C. elegans CO formation have been unclear. In this issue of PLOS Genetics, Agostinho et al., Saito et al., and O’Neil et al. demonstrate that MUS-81 and XPF-1 function in two parallel pathways during the formation of meiotic crossovers in C. elegans and provide important insights into the interplay between endonucleases and the Bloom helicase ortholog during crossover formation.