Research Article: Antiviral and Virucidal Activities of Nα-Cocoyl-L-Arginine Ethyl Ester

Date Published: November 28, 2011

Publisher: Hindawi Publishing Corporation

Author(s): Hisashi Yamasaki, Kazuko Tsujimoto, Keiko Ikeda, Yukiko Suzuki, Tsutomu Arakawa, A. Hajime Koyama.


Various amino acid-derived compounds, for example, Nα-Cocoyl-L-arginine ethyl ester (CAE), alkyloxyhydroxylpropylarginine, arginine cocoate, and cocoyl glycine potassium salt (Amilite), were examined for their virucidal activities against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2), influenza A virus (IAV), and poliovirus type 1 (PV-1) in comparison to benzalkonium chloride (BKC) and sodium dodecylsulfate (SDS) as a cationic and anionic control detergent and also to other commercially available disinfectants. While these amino acid-derived compounds were all effective against HSV-1 and HSV-2, CAE and Amilite were the most effective. These two compounds were, however, not as effective against IAV, another enveloped virus, as against HSV. Cytotoxicity of CAE was weak; at 0.012%, only 5% of the cells were killed under the conditions, in which 100% cells were killed by either SDS or BKC. In addition to these direct virucidal effects, CAE inhibited the virus growth in the HSV-1- or PV-1-infected cells even at 0.01%. These results suggest a potential application of CAE as a therapeutic or preventive medicine against HSV superficial infection at body surface.

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Recently there has been an increasing necessity for a multitude of preparedness against infectious diseases. Every year we encounter emerging and reemerging infectious diseases. While vaccination is a primary strategy to overcome viral diseases [1], vaccines are not readily available for many viruses and, even if available, not accessible for every individual due to various reasons (e.g., cost, distribution, and politics). Another compounding problem with virus infection is that antiviral drugs are not available for many viral diseases [2]. Disinfection at body surface, such as hand sanitization, has been an effective measure for the prevention against viral diseases and even applicable for the therapy of certain viral diseases, provided that its tissue toxicity can be tolerated [3].




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