Research Article: Association of tumour necrosis factor-α (TNF-α) gene polymorphisms (-308 G>A and -238 G>A) and the risk of severe dengue: A meta-analysis and trial sequential analysis

Date Published: October 9, 2018

Publisher: Public Library of Science

Author(s): Cho Naing, Norah Htet Htet, Wong Siew Tung, Arun Kumar Basavaraj, Joon Wah Mak, Han-Chung Wu.


Individual studies have assessed the association between TNF-α-308G>A and TNF-α-238 G>A polymorphisms and severity of dengue infection. However, the results are inconclusive and most studies had small sample sizes. The objective of this study was to summarize the evidence of association between TNF-α-308 G>A and TNF-α-238 G>A and severity of dengue infection.

Partial Text

Dengue fever is endemic in the tropics and sub-tropics and it is the most common arboviral infection caused by dengue viruses (DENV-1, -2, -3, and -4), which are transmitted primarily by the bite of Aedes aegypti and Ae. albopictus mosquitoesThe clinical manifestations of DENV infection vary from mild (asymptomatic, undifferentiated fever, dengue fever) to the severe form of dengue haemorrhagic fever (DHF). It is estimated that 2.5 billion people worldwide are at risk for DENV infection. About 5% of those at risk will have severe forms such as DHF and dengue shock syndrome (DSS), which are potentially fatal [1,2].

The current study conformed to the checklist for meta-analysis of genetic association studies specified for PLOS One approach [13] (S1 Table).




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