Research Article: Associations between GLUT expression and SUV values derived from FDG-PET in different tumors—A systematic review and meta analysis

Date Published: June 17, 2019

Publisher: Public Library of Science

Author(s): Hans-Jonas Meyer, Andreas Wienke, Alexey Surov, Pankaj K Singh.

http://doi.org/10.1371/journal.pone.0217781

Abstract

Fluorodeoxyglucose-Positron-emission tomography (FDG-PET), quantified by standardized uptake values (SUV), is one of the most used functional imaging modality in clinical routine. It is widely acknowledged to be strongly associated with Glucose-transporter family (GLUT)-expression in tumors, which mediates the glucose uptake into cells. The present systematic review sought to elucidate the association between GLUT 1 and 3 expression with SUV values in various tumors.

MEDLINE library was screened for associations between FDG-PET parameters and GLUT correlation cancer up to October 2018.

There were 53 studies comprising 2291 patients involving GLUT 1 expression and 11 studies comprising 405 patients of GLUT 3 expression. The pooled correlation coefficient for GLUT 1 was r = 0.46 (95% CI 0.40–0.52), for GLUT 3 was r = 0.35 (95%CI 0.24–0.46). Thereafter, subgroup analyses were performed. The highest correlation coefficient for GLUT 1 was found in pancreatic cancer r = 0.60 (95%CI 0.46–0.75), the lowest was identified in colorectal cancer with r = 0.21 (95% CI -0.57–0.09).

An overall only moderate association was found between GLUT 1 expression and SUV values derived from FDG-PET. The correlation coefficient with GLUT 3 was weaker. Presumably, the underlying mechanisms of glucose hypermetabolism in tumors are more complex and not solely depended on the GLUT expression.

Partial Text

Fluorodeoxyglucose -Positron-emission tomography (FDG-PET) is one of the most used functional imaging modality in clinical practice. The value of this imaging technique is based upon the display of glucose metabolism in vivo [1, 2]. This benefit has been extensively researched, especially in the field of oncologic imaging. The FDG uptake is routinely quantified by standardized uptake values (SUV), which is a robust and reliable imaging biomarker [1, 2].

The present systematic review represents a meta analysis elucidating the associations between SUVmax derived from FDG-PET and GLUT expression in various tumors.

In summary, the present systematic review identified only a moderate association between GLUT 1 expression and SUV values derived from FDG-PET. Moreover, the correlation between SUV and GLUT 1 varied significantly in different tumors. SUV correlated weakly with expression of GLUT 3. Presumably, the underlying mechanisms of glucose hypermetabolism in tumors are more complex and not solely depended on the GLUT expression.

 

Source:

http://doi.org/10.1371/journal.pone.0217781