Date Published: October 12, 2010
Publisher: Public Library of Science
Author(s): Wayne D. Hall, Rebecca Mathews, Katherine I. Morley
Abstract: Wayne Hall and colleagues discuss the limitations of genomic risk prediction for population-level preventive health care.
Partial Text: In the 1990s, during the era of the Human Genome Project, many researchers were very optimistic about the capacity of such large-scale genetic projects to revolutionize the prevention of disease (e.g., ,). Many predicted that whole populations would be screened for their genetic susceptibility to common diseases, such as cancer and heart disease. Healthy individuals who carried susceptibility alleles would be advised to change their behaviour (e.g., exercise more, maintain a healthier diet, stop smoking), or be given drugs or other treatments to reduce their risks of developing these diseases.