Research Article: Being More Realistic about the Public Health Impact of Genomic Medicine

Date Published: October 12, 2010

Publisher: Public Library of Science

Author(s): Wayne D. Hall, Rebecca Mathews, Katherine I. Morley

Abstract: Wayne Hall and colleagues discuss the limitations of genomic risk prediction for population-level preventive health care.

Partial Text: In the 1990s, during the era of the Human Genome Project, many researchers were very optimistic about the capacity of such large-scale genetic projects to revolutionize the prevention of disease (e.g., [1],[2]). Many predicted that whole populations would be screened for their genetic susceptibility to common diseases, such as cancer and heart disease. Healthy individuals who carried susceptibility alleles would be advised to change their behaviour (e.g., exercise more, maintain a healthier diet, stop smoking), or be given drugs or other treatments to reduce their risks of developing these diseases.



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