Research Article: Bioceramic cement in the filling of bone defects in rats1

Date Published: August 19, 2019

Publisher: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia

Author(s): Christiano Cândido Zerbinatti, Daniela Francescato Veiga, Monique Amanda Bastista Oliveira, Fiorita Gonzales Lopes Mundim, Rodrigo Machado Pereira, Francisco Azevedo, Taylor Brandão Schnaider, José Dias da Silva.


To evaluate PBS®MCIMMO cement in the filling of bone defects.

Thirty-six adult male Wistar rats were divided into three groups of twelve individuals each (group 1, group 2 and group 3). In all groups, a bone failure in the femur was induced, 2.0 mm wide and 7.0 mm deep. In group 1, the PBS®MCIMMO cement was applied to the bone defect produced and a titanium implant (CONNECTION®) 1.5 mm thick and 6 mm long was installed. In group 2, only the PBS® CIMMO cement was installed. In group 3, only bone failure was performed. Kruskal Wallis tests were performed to compare the mean area among the three groups.

In all comparisons, significance was observed for group 2 (p = 0.0014–0.0026).

The PBS®CIMMO cement induced bone neoformation, and integration between the newly formed bone, cement, and implant was observed.

Partial Text

The exodontia of anterior dental elements induces bone failure requiring immediate aesthetic reconstruction through the installation of implants and the preparation of provisional or definitive prosthesis. Autologous, homologous or allogeneic bone grafts do not allow immediate procedures. Using biomaterials to preserve the architecture of the alveolus – height and width – would allow immediate aesthetic reconstruction1-3.

The project was submitted to the Committee on Ethics in the Use of Animals (CEUA) and approved under opinion 265/17.

The histomorphometry data of bone neoformation in groups 1, 2, and 3 were analyzed by measuring three areas (A, B and C) in the photomicrographs. The Kruskal Wallis test was performed to compare the mean area among the three groups. In all comparisons group 2 was significantly different from the other groups (p = 0.0014–0.0026, Table 1).

Exodontia is indicated in the following situations: trauma causing irreversible root fractures, secondary endodontic infections, and periodontal diseases that resist conventional treatments. The practitioner who performs the rehabilitation will face the problem of changes in bone continuity – bone defects – or segmental bone loss preventing immediate implantation18. A constant problem in the clinical practice of implant dentistry is the indication of extraction of dental elements in aesthetically relevant regions. In most cases, the immediate aesthetic reconstruction with implants and the preparation of provisional or definitive prosthesis is essential. However, bone failures need to be regenerated prior to implant installation that will replace the dental root, due to the lack of bone structure to support the implant. This process, called guided bone regeneration (GBR) requires time, when conventional techniques such as autologous, homologous, or allogeneic bone grafts are used7,12,20and thus aesthetics will be compromised1.

The cement PBS®CIMMO induced bone neoformation and integration was observed involving the newly formed bone, the cement, and the titanium screw.




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