Research Article: Crystal structure of a methimazole-based ionic liquid

Date Published: December 01, 2015

Publisher: International Union of Crystallography

Author(s): Jamie C. Gaitor, Manuel Sanchez Zayas, Darrel J. Myrthil, Frankie White, Jeffrey M. Hendrich, Richard E. Sykora, Richard A. O’Brien, John T. Reilly, Arsalan Mirjafari.

http://doi.org/10.1107/S2056989015022136

Abstract

The structure of 1-methyl-2-(prop-2-en-1-ylsulfan­yl)-1H-imidazol-3-ium bromide, C7H11N2S+·Br−, has monoclinic (P21/c) symmetry. In the crystal, the components are linked by N—H⋯Br and C—H⋯Br hydrogen bonds. The crystal structure of the title compound undeniably proves that methimazole reacts through the thione tautomer, rather than the thiol tautomer in this system.

Partial Text

For the biological activity of methimazole, see: Rong et al. (2013 ▸). For its use as a ligand, see: Crossley et al. (2006 ▸). For a discussion of methimazole-based ionic liquids, see: Siriwardana et al. (2008 ▸). For reaction chemistry of methimazole, see: Roy & Mugesh (2005 ▸).

 

Source:

http://doi.org/10.1107/S2056989015022136