Research Article: Deciphering the role of Nuclear Factor-κB in cellular senescence

Date Published: October 26, 2011

Publisher: Impact Journals LLC

Author(s): Simon Vaughan, Parmjit S. Jat.

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Abstract

Cellular senescence is a program of irreversible cell cycle arrest that cells undergo in response to a variety of intrinsic and extrinsic stimuli including progressive shortening of telomeres, changes in telomeric structure or other forms of genotoxic and non-genotoxic stress. The role of nuclear factor-κB in cellular senescence is controversial, as it has been associated with both proliferation and tumour progression, and also with growth arrest and ageing. This research perspective focuses on the evidence for a functional relationship between NF-κB and senescence, and how disruption of the NF-κB pathway can lead to its bypass.

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