Date Published: June 13, 2019
Publisher: Public Library of Science
Author(s): Kelly K. Ferguson, Zaira Rosario, Thomas F. McElrath, Carmen Vélez Vega, José F. Cordero, Akram Alshawabkeh, John D. Meeker, Emma Sacks.
Preterm birth is a major public health problem, especially in Puerto Rico where the rates are among the highest observed worldwide, reaching 18% in 2011. The Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) study is an ongoing investigation of environmental factors that contribute to this condition. In the present analysis, we sought to examine common risk factors for preterm birth and other adverse birth outcomes which have not been characterized previously in this unique population. Pregnant women from the PROTECT cohort are recruited from the heavily contaminated Northern coast of the island of Puerto Rico and are free of pre-existing conditions like diabetes. We examined associations between basic demographic, behavioral (e.g., tobacco and alcohol use), and pregnancy (e.g., season and year of delivery) characteristics as well as municipality of residence in relation to preterm birth (<37 weeks gestation), postterm birth (≥41 weeks gestation), and small and large for gestational age in univariate and multivariate logistic regression models. Between 2011 and 2017, 1028 live singleton births were delivered as part of the PROTECT cohort. Of these, 107 (10%) were preterm. Preterm birth rates were higher among women with low socioeconomic status, as indicated by education level and income, and among women with high pre-pregnancy body mass index (BMI). Odds ratios of small for gestational age delivery were higher for women who reported tobacco use in pregnancy and lower for women who delivered in the hurricane and dengue season (July-October). Overall, in pregnant women residing in Puerto Rico, socioeconomic status was associated with preterm birth but few other factors were associated with this or other adverse outcomes of pregnancy. Research to understand environmental factors that could be contributing to the preterm birth epidemic in Puerto Rico is necessary.
Preterm birth is a global health problem that has major public health and economic consequences . In Puerto Rico, the rate of preterm birth is particularly high. In 2011, the island of Puerto shared the highest rate of preterm birth in the United States with Mississippi at 18% , which is also among the highest rates worldwide . By 2017, this decreased considerably to 11% . However, this still ranks among the highest rates of preterm birth, especially for highly developed countries, but also in the world [3, 5]. Thus, identifying factors contributing to preterm birth in Puerto Rico deserves special attention.
PROTECT study participants are recruited on the island’s heavily contaminated northern coast at two collaborating hospitals and five nearby health clinics. All participants are recruited from clinics located in Camuy, Lares, Morovis, Quebradillas, and Ciales, and intend to deliver at one of the two collaborating hospitals: Manatí Medical Center and Arecibo’s Cayetano Coll y Toste Hospital. Pregnant women visiting the clinics or hospitals are recruited at approximately 14 weeks gestation and are eligible for inclusion in the study if they are between the ages of 18 and 40 years, reside in a municipality in the Northern karst region of the island, did not use oral contraceptives for at least three months prior to becoming pregnant, did not use in vitro fertilization to become pregnant, and were free of known medical or obstetrical complications, including pre-existing diabetes . If eligible, women are invited to participate and asked to fill out an initial screening form to collect brief information on demographic characteristics and estimated date of last menstrual period (LMP). The study was described in detail to all participants, and written informed consent was obtained prior to study enrollment.
The present analysis includes 1028 singleton live births from PROTECT participants who delivered between August 2011 and the end of July of 2017 and who had confirmed delivery and a reported date of LMP on the initial screening form (Fig 1). Ultrasounds for confirming estimated gestational age based on LMP were available for 782 participants (76%). The American College of Obstetricians and Gynecologists (ACOG) recommends redating LMP-based estimated date of delivery if the estimates of gestational age based on LMP differ from ultrasound estimates by a certain number of days, depending on the time of the scan . Table A in S2 File shows the criteria suggested by ACOG for redating based on gestational age at ultrasound, and the number of participants from PROTECT that fell into each category. Most participants who had ultrasounds available for dating had them performed before 14 weeks gestation (n = 693). Overall, gestational age was changed from the LMP estimate to the ultrasound estimate for 171 pregnancies , and the change in final gestational age was minimal (mean = 0.25 weeks, standard deviation = 0.13 weeks).
Driven by the high preterm birth rates observed in Puerto Rico, the objective of the PROTECT study is to investigate the origins of this disease. The present analysis takes the first step toward understanding this problem by examining risk factors that have been associated with preterm birth in other study populations, and investigating them for the first time among pregnant women in Puerto Rico. We observed that low socioeconomic status, particularly as indicated by education level, was associated with increased risk of preterm birth, as was high BMI. On the other hand, maternal tobacco use in pregnancy and delivery during the hurricane and dengue season (i.e., gestation largely occurring outside of this period) were associated with increased risk of delivering a baby small for gestational age. These findings are consistent with results from other cohort studies in the US and worldwide, but, importantly, have not been previously shown in a population of pregnant women residing in Puerto Rico.
In summary, in a large prospective study of pregnancy in Puerto Rico, we examined for the first time demographic, behavioral, and pregnancy-related risk factors for adverse birth outcomes including preterm and postterm birth as well as small- and large- for gestational age. The most notable findings were associations between low income and education level in relation to preterm birth. Environmental factors including chemical exposures may play an important in the etiology of adverse pregnancy outcomes but have yet to be explored in Puerto Rico. As recruitment into the PROTECT cohort study continues, this analysis will serve as an important reference for understanding of risk and contributing factors to adverse pregnancy outcomes prior to the spread of Zika to the island and the catastrophe of Hurricanes Irma and Maria.