Research Article: Diisopropyl {[(R)-2-(2-amino-6-chloro-9H-purin-9-yl)-1-methyl­eth­oxy]meth­yl}­phospho­nate

Date Published: April 01, 2012

Publisher: International Union of Crystallography

Author(s): Guobao Zhao, Xinhua He, Bohua Zhong.


In the title compound, C15H25ClN5O4P, the r.m.s. deviation for the purine ring system is 0.0165 Å. The coordination about the P atom is a distorted tetrahedron [O=P—O angles = 116.70 (6) and 109.87 (6)°]. In the crystal, molecules are linked by N—H⋯O hydrogen bonds, generating a three-dimensional network.

Partial Text

For details of the synthesis, see: Yu et al. (1992 ▶). For the bioactivity of nucleoside analogues, see: Martin (1989 ▶). For reference bond lengths, see: Allen et al. (1987 ▶). For a related structure, see: Baszczyňski et al. (2011 ▶).