Research Article: dl-Methyl 4-(4-meth­oxy­phen­yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexa­hydro­quinoline-3-carboxyl­ate

Date Published: March 01, 2012

Publisher: International Union of Crystallography

Author(s): Jing-Min Zhao.


In the title compound, C21H25NO4, the dihydropyridine ring adopts a flattened boat conformation. The N atom and the sp3 C atom deviate in the same direction from the mean plane of the other four C atoms, by 0.269 (6) and 0.111 (6) Å, respectively. This mean plane is inclined to the 4-methoxy­phenyl ring by 87.3 (5)°. The cyclohexenone ring has a sofa conformation with the C atom bearing the methyl groups deviating from the mean plane through the other five C atoms by 0.628 (6) Å. There is a short C—H⋯O hydrogen bond in the molecule. In the crystal, molecules are linked by an N—H⋯O hydrogen bond to form chains propagating along the c-axis direction.

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For related structures and hydrogen-bond definition, see: Yang et al. (2010 ▶). For the syntheis method, see: Tamaddon et al. (2010 ▶); Yang et al. (2011 ▶). For related literature about the biological activity of 1,4-dihydropyridines and their derivatives, see: Davies et al. (2005 ▶); Rose & Draeger (1992 ▶); Warrior et al. (2005 ▶).