Date Published: December 22, 2003
Publisher: Public Library of Science
Partial Text: Each year some 29,000 American men die of prostate cancer. With about 221,000 more diagnoses expected in the United States in 2003, the disease trails only skin cancer as the most common male cancer. As a complex disease, multiple genetic and environmental factors contribute to risk and, like most cancers, its onset and progression depends on the combination of a series of genetic disruptions rather than on a single event. But as Pier Paolo Pandolfi and colleagues report, protein “dose”—that is, the level of remaining activity—also influences cancer progression.