Research Article: (E)-3-(4-Cyclo­hexyl-3-fluoro­benzyl­idene)chroman-4-one

Date Published: June 01, 2012

Publisher: International Union of Crystallography

Author(s): Kaalin Gopaul, Mahidansha M. Shaikh, Neil A. Koorbanally, Deresh Ramjugernath, Bernard Omondi.


The title compound, C22H21FO2, exhibits substitutional disorder of the F atom and a H atom in the asymmetric unit with different occupancies, the refined F:H ratio being 0.80 (2):0.20 (2). The dihedral angle between the fluorinated benzene ring and the benzene ring of the chromanone system is 37.30°. There are two relatively high residual electron-density peaks associated with the disorder.

Partial Text

For the preparation, see: Shaikh et al. (2011 ▶). For related structures, see: Gopaul et al. (2012 ▶); Marx et al. (2008 ▶); Suresh et al. (2007 ▶). For the biological activity of this class of compound, see: du Toit et al. (2010 ▶). This compound may undergo chemical conversion into the (E)- and (Z)-isomers, see: Kirkiacharian et al. (1984 ▶).




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