Date Published: May 01, 2010
Publisher: International Union of Crystallography
Author(s): Burkhon Zh Elmuradov, Kambarali Turgunov, Bakhodir Tashkhodjaev, Khusniddin M. Shakhidoyatov.
The title compound, C15H16N2O2·H2O, was synthesized via the alkylation of 3-hydroxymethylidene-2,3-dihydro-1H-pyrrolo[2,1-b]quinazolin-9-one with n-propyl iodide in the presence of sodium hydroxide. The organic molecule and the water molecule both lie on a crystallographic mirror plane. In the crystal structure, intermolecular O—H⋯O and O—H⋯N hydrogen bonds link the components into extended chains along .
For the synthesis of the title compound and its derivatives, see: Späth & Platzer, (1935 ▶); Shakhidoyatov et al. (1976 ▶); Oripov et al. (1979 ▶); Elmuradov et al. (2006 ▶); Elmuradov & Shakhidoyatov (2004 ▶); Jahng et al. (2008 ▶). For the physiological activity of the title compound and its derivatives, see: Amin & Mehta (1959 ▶); Chatterjee & Ganguly (1968 ▶); Yakhontov et al. (1977 ▶); Yunusov et al. (1978 ▶); Johne (1981 ▶); Shakhidoyatov (1988 ▶). For standard bond distances, see: Allen et al. (1987 ▶).