Date Published: April 01, 2012
Publisher: International Union of Crystallography
Author(s): Mashooq A. Bhat, Hatem A. Abdel-Aziz, Hazem A. Ghabbour, Madhukar Hemamalini, Hoong-Kun Fun.
In the title compound, C16H17N3O·H2O, the isonicotinohydrazide molecule adopts an E conformation about the central C=N double bond. The dihedral angle between the pyridine and the benzene rings is 54.56 (15)°. In the crystal, molecules are connected via N—H⋯O, O—H⋯N and O—H⋯O hydrogen bonds, forming a three-dimensional network.
For details and the biological activity of isoniazide, see: Bloom & Murray (1992 ▶); Loenhout-Rooyackers & Veen (1998 ▶); Hearn et al. (2009 ▶); Tripathi et al. (2011 ▶).