Research Article: Early warning systems in obstetrics: A systematic literature review

Date Published: May 31, 2019

Publisher: Public Library of Science

Author(s): Aminu Umar, Charles A. Ameh, Francis Muriithi, Matthews Mathai, Shane Patman.


Several versions of Early Warning Systems (EWS) are used in obstetrics to detect and treat early clinical deterioration to avert morbidity and mortality. EWS can potentially be useful to improve the quality of care and reduce the risk of maternal mortality in resource-limited settings. We conducted a systematic literature review of published obstetric early warning systems, define their predictive accuracy for morbidity and mortality, and their effectiveness in triggering corrective actions and improving health outcomes.

We systematically searched for primary research articles on obstetric EWS published in peer-reviewed journals between January 1997 and March 2018 in Medline, CINAHL, SCOPUS, Science Direct, and Science Citation Index. We also searched reference lists of relevant articles and websites of professional societies. We included studies that assessed the predictive accuracy of EWS to detect clinical deterioration, or/and their effectiveness in improving clinical outcomes in obstetric inpatients. We excluded studies with a paediatric or non-obstetric adult population. Cross-sectional and qualitative studies were also excluded. We performed a narrative synthesis since the outcomes reported were heterogeneous.

A total of 381 papers were identified, 17 of which met the inclusion criteria. Eleven of the included studies evaluated the predictive accuracy of EWS for obstetric morbidity and mortality, 5 studies assessed the effectiveness of EWS in improving clinical outcomes, while one study addressed both. Sixteen published EWS versions were reviewed, 14 of which included five basic clinical observations (pulse rate, respiratory rate, temperature, blood pressure, and consciousness level). The obstetric EWS identified had very high median (inter-quartile range) sensitivity—89% (72% to 97%) and specificity—85% (67% to 98%) but low median (inter-quartile range) positive predictive values—41% (25% to 74%) for predicting morbidity or ICU admission. Obstetric EWS had a very high accuracy in predicting death (AUROC >0.80) among critically ill obstetric patients. Obstetric EWS improves the frequency of routine vital sign observation, reduces the interval between the recording of specifically defined abnormal clinical observations and corrective clinical actions, and can potentially reduce the severity of obstetric morbidity.

Obstetric EWS are effective in predicting severe morbidity (in general obstetric population) and mortality (in critically ill obstetric patients). EWS can contribute to improved quality of care, prevent progressive obstetric morbidity and improve health outcomes. There is limited evidence of the effectiveness of EWS in reducing maternal death across all settings. Clinical parameters in most obstetric EWS versions are routinely collected in resource-limited settings, therefore implementing EWS may be feasible in such settings.

Partial Text

The World Health Organization (WHO) estimated 303, 000 maternal deaths globally in 2015 at the end of the Millennium Development Goals era [1]. Over 99% of these deaths occurred in low-income settings [1]. It is also estimated that there were 27 million episodes of direct obstetric complications annually that contribute to long-term pregnancy and childbirth complications [2]. Good quality care including timely identification and management of obstetric complications can contribute to reducing the burden of maternal deaths and associated long-term complications [2].

Our search identified 381 papers (Medline = 152, Scopus = 24, CINAHL = 43, Science Citation Index = 88, Science Direct = 49, Clinical trials. gov = 11 and other sources = 14). Ten publications were available only as conference abstracts; authors of six of these abstracts confirmed unavailability of full texts. Seventeen papers met the inclusion criteria and were included in the review Fig 2, S2 Table. All studies that assessed the predictive accuracy of EWS for adverse obstetric outcomes were observational studies.

Our systematic review did not identify any randomised controlled trials on EWS. It included 17 studies, mostly observational studies [11] and only two of all included studies were conducted in low-income countries. All studies that assessed the predictive accuracy of EWS for adverse obstetric outcomes were observational studies. Most of the studies that assessed the effectiveness of EWS in improving clinical outcomes were of quasi-experimental design.

Obstetric EWS are highly sensitive and specific in predicting obstetric morbidity and ICU admission with relatively low, but comparatively acceptable PPV. This supports their utility as valuable bedside screening tools for morbidity among the general obstetric population. Early warning systems are highly accurate in predicting maternal death among critically ill obstetric patients, but there is limited evidence of their effectiveness in reducing maternal deaths. Obstetric EWS may improve the frequency of routine vital sign observation and may reduce the interval between patient deterioration and corrective clinical action. These can potentially improve the quality of care for pregnant/postpartum women and reduce the risk of adverse obstetric outcomes. Most obstetric EWS versions have basic clinical observations that can be routinely collected in resource-limited settings making them feasible for use in such settings. More robust studies are however needed to assess the effectiveness of obstetric EWS in reducing maternal deaths.




Leave a Reply

Your email address will not be published.