Date Published: September 28, 2010
Publisher: Public Library of Science
Author(s): Vincent Gajdos, Sandrine Katsahian, Nicole Beydon, Véronique Abadie, Loïc de Pontual, Sophie Larrar, Ralph Epaud, Bertrand Chevallier, Sylvain Bailleux, Alix Mollet-Boudjemline, Jean Bouyer, Sylvie Chevret, Philippe Labrune, Rosalind Louise Smyth
Abstract: Vincent Gajdos and colleagues report results of a randomized trial conducted among hospitalized infants with bronchiolitis. They show that a physiotherapy technique (increased exhalation and assisted cough) commonly used in France does not reduce time to recovery in this population.
Partial Text: Acute viral bronchiolitis is generally a self-limiting condition and is most commonly associated with respiratory syncytial virus (RSV) infection. It is the most common lower respiratory tract infection in the first years of life, and it is usually a mild to moderate disease. However, some infants develop severe disease and hospitalization is necessary in about 1% of previously healthy infected infants –. Recent population-based studies have shown that mean annual hospitalization rates for conditions related to RSV infection were between 5 and 17 per 1,000 children under 12 mo of age ,.
This study provides an evaluation of chest physiotherapy with IET + AC in a large population of infants hospitalized for a first episode of bronchiolitis with time to recovery as the primary endpoint. In this seven-center trial, no evidence of any difference in time to recovery between the IET + AC group and the NS group was found, with no interaction with age group. The CIs around estimates of effect excluded a clinically meaningful difference in time to recovery between groups in the whole population.