Research Article: Endocrine responses and food intake in fasted individuals under the influence of glucose ingestion

Date Published: January 25, 2019

Publisher: Public Library of Science

Author(s): Janis Marc Nolde, Jana Laupenmühlen, Arkan Al-Zubaidi, Marcus Heldmann, Thomas F. Münte, Kamila Jauch-Chara, Domenico Tricò.

http://doi.org/10.1371/journal.pone.0211514

Abstract

Different metabolic conditions can affect what and how much we eat. Hormones of glucose metabolism and adipokines such as adiponectin take part in the control of these decisions and energy balance of the body. However, a comprehensive understanding of how these endocrine and metabolic factors influence food intake has not been reached. We hypothesised that the amount of food a person consumes differs substantially after a fasting period even after the energy deficit was partially removed by glucose ingestion and endocrine signals like insulin and C-peptide indicated a high glucose metabolic status. Furthermore, the macronutrient composition of the consumed food and a possible association with adiponectin under the influence of glucose ingestion was assessed.

In a within-subject design, 24 healthy males participated in both a fasting (42 h) and control (non-fasting) condition. A total of 20 blood samples from each subject were collected during each condition to assess serum levels of adiponectin, insulin, C-peptide, cortisol and ACTH. At the end of each condition food intake was measured with an ad libitum buffet after the acute energy deficit was compensated using a carbohydrate-rich drink.

The total amount of caloric intake and single macronutrients was higher after the fasting intervention after replenishment with glucose. All recorded hormone levels, except for adiponectin, were significantly different for at least one of the study intervals. The relative proportions of the macronutrient composition of the consumed food were stable in both conditions under the influence of glucose ingestion. In the non-fasting condition, the relative amount of protein intake correlated with adiponectin levels during the experiment.

An anabolic glucose metabolism after glucose ingestion following a fasting intervention did not even out energy ingestion compared to a control group with regular food intake and glucose ingestion. Anorexigenic hormones like insulin in this context were not able despite higher levels than in the control condition to ameliorate the drive for food intake to normal or near normal levels. Relative macronutrient intake remains stable under these varying metabolic conditions and glucose influence. Serum adiponectin levels showed a positive association with the relative protein intake in the non-fasting condition under the influence of glucose although adiponectin levels overall did not differ in between the conditions.

Partial Text

Both obesity and its associated metabolic disorders have become a global health burden in recent years [1]. Excessive calorie intake and macronutrient composition of consumed food are major factors in the development of this obesity pandemic [2–5]. Therefore, investigation into the quantity and food composition an individual consumes and why may assist in developing a more comprehensive understanding of how metabolic disorders develop.

This study compared food intake after either fasting or non-fasting periods when an acute caloric deficit was partially removed by oral glucose towards the end of the experiment. Whereas the total quantity of food ingested differed between conditions, the relative proportion of each macronutrient consumed did not. The relative amount of protein intake in the non-fasting condition correlated positively with the AUC-value of adiponectin throughout the experiment.

 

Source:

http://doi.org/10.1371/journal.pone.0211514

 

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