Research Article: Ethyl 2-(3-phenyl­thio­ureido)-5,6-di­hydro-4H-cyclo­penta­[b]thio­phene-3-carboxyl­ate

Date Published: August 01, 2012

Publisher: International Union of Crystallography

Author(s): Jaismary G. B. de Oliveira, Francisco J. B. Mendonça Junior, Maria do Carmo A. de Lima, Carlos A. de Simone, Javier A. Ellena.


In the title compound, C17H18N2O2S2, the angle between the mean plane defined by the atoms of the 5,6-dihydro-4H-cyclo­penta­[b]thio­phene moiety (r.m.s. deviation = 0.19 Å) and the phenyl ring is 72.8°(2). The mol­ecular conformation is stabilized by an intra­molecular N—H⋯O inter­action, which generates an S(6) ring motif. In the crystal, pairs of N—H⋯S hydrogen bonds link the mol­ecules to form inversion dimers with an R22(8) ring motif.

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For background to 2-amino­thio­phene derivatives, see: Puterová et al. (2010 ▶). For the biological activity of 2-ureido- and 2-thio­ureido-thio­phene-3-carboxyl­ate derivatives, see: Arhin et al. (2006 ▶); Saeed et al. (2010 ▶). For the synthesis of 2-amino­thio­phenes, see: Gewald et al. (1966 ▶). For a related structure, see: Larson & Simonsen (1988 ▶). For hydrogen-bond motifs, see: Bernstein et al. (1995 ▶).




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