Date Published: August 01, 2012
Publisher: International Union of Crystallography
Author(s): Jaismary G. B. de Oliveira, Francisco J. B. Mendonça Junior, Maria do Carmo A. de Lima, Carlos A. de Simone, Javier A. Ellena.
In the title compound, C17H18N2O2S2, the angle between the mean plane defined by the atoms of the 5,6-dihydro-4H-cyclopenta[b]thiophene moiety (r.m.s. deviation = 0.19 Å) and the phenyl ring is 72.8°(2). The molecular conformation is stabilized by an intramolecular N—H⋯O interaction, which generates an S(6) ring motif. In the crystal, pairs of N—H⋯S hydrogen bonds link the molecules to form inversion dimers with an R22(8) ring motif.
For background to 2-aminothiophene derivatives, see: Puterová et al. (2010 ▶). For the biological activity of 2-ureido- and 2-thioureido-thiophene-3-carboxylate derivatives, see: Arhin et al. (2006 ▶); Saeed et al. (2010 ▶). For the synthesis of 2-aminothiophenes, see: Gewald et al. (1966 ▶). For a related structure, see: Larson & Simonsen (1988 ▶). For hydrogen-bond motifs, see: Bernstein et al. (1995 ▶).