Research Article: Ethyl 2-(4-carb­oxy­benzyl­idene)-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-thia­zolo[3,2-a]pyrimidine-6-carboxyl­ate–N,N-dimethyl­formamide (1/1)

Date Published: February 01, 2012

Publisher: International Union of Crystallography

Author(s): Noor Afshan Banu, V. Bheema Raju.

http://doi.org/10.1107/S1600536812000050

Abstract

In the title compound, C24H20N2O5S·C3H7NO, a benzene ring is positioned axially to the pyrimidine ring, which adopts a twist-boat conformation, and is inclined to its mean plane by 85.36 (7)°. In the crystal, inter­molecular C—H⋯O inter­actions result in centrosymmetric head-to-head dimers with an R22(14) graph-set motif along the b axis. Pairs of C—H⋯O and O—H⋯O hydrogen bonds form centrosymmetric head-to-head dimers about inversion centres, corresponding to an R22(7) graph-set motif along the a axis.

Partial Text

For pharmacological properties of pyrimidine derivatives and general background, see: Alam et al. (2010 ▶). For a related structure, see: Jotani et al. (2010 ▶). For graph-set motifs, see: Bernstein et al. (1995 ▶). For puckering parameters, see: Cremer & Pople (1975 ▶).

 

Source:

http://doi.org/10.1107/S1600536812000050